Question 1

Methicillin is an example of the beta-lactam class of drugs that

Accepted Answer

A)   disrupt cytoplasmic membranes.
B)   inhibit cell wall synthesis.
C)   inhibit nucleic acid synthesis.
D)   inhibit metabolic pathways.
E)   inhibit protein synthesis.F) A) and E)
G) A) and D) B

Question 2

Examine the diffusion susceptibility plate results shown in Figure 10.9. Propose an explanation for the appearance of the zone around the AM/10 disk, and discuss the implications for therapeutic use of this antibiotic for the pathogen tested.

Accepted Answer

The ring of colonies within the outermos...

Question 3

Competition between beneficial microbes and potential pathogens is called microbial __________.

Accepted Answer

The answer of Competition between beneficial microbes and potential pathogens...

Question 4

Paul Erhlich coined the term antibiotics for the "magic bullet" antimicrobials he pursued.

Accepted Answer

A) True 
 B)False

Question 5

Which of the following groups of drugs can become incorporated into the bones and teeth of a fetus?

Accepted Answer

A)   beta-lactams
B)   aminoglycosides
C)   quinolones
D)   tetracyclines
E)   sulfonamidesF) A) and D)
G) A) and E)

Question 6

Which of the following pathways is specifically inhibited by sulfonamides?

Accepted Answer

A)   the conversion of tetrahydrofolic acid to PABA
B)   the conversion of PABA to dihydrofolic acid
C)   the conversion of dihydrofolic acid to tetrahydrofolic acid
D)   the conversion of PABA to tetrahydrofolic acid
E)   the conversion of dihydrofolic acid to PABAF) A) and B)
G) A) and C)

Question 7

Brain and spinal cord infections are difficult to treat because most antimicrobial drugs cannot diffuse out of the blood into these organs.

Accepted Answer

A) True 
 B)False

Question 8

The tetracyclines interfere with

Accepted Answer

A)   protein synthesis.
B)   cell wall synthesis.
C)   cell membrane component synthesis.
D)   nucleic acid synthesis.
E)   folic acid synthesis.F) B) and E)
G) A) and E)

Question 9

If a subculture of an MIC test grows in an MBC test, the concentration of the drug was bactericidal.

Accepted Answer

A) True 
 B)False

Question 10

Which scientist coined the term antibiotic?

Accepted Answer

A)   Fleming
B)   Domagk
C)   Kirby
D)   Ehrlich
E)   WaksmanF) C) and E)
G) B) and C) E

Question 11

Discuss the cellular factors that might make a drug's spectrum of action narrow rather than broad.

Accepted Answer

When a drug is labeled "narrow-spectrum,...

Question 12

Selective __________ means that a given antimicrobial agent is more toxic to a pathogen than to the host being treated.

Accepted Answer

The answer of Selective __________ means that a given antimicrobial...

Question 13

Antimicrobials that block protein synthesis by binding to the mRNA are

Accepted Answer

A)   aminoglycosides.
B)   antisense nucleic acids.
C)   macrolides.
D)   beta-lactams.
E)   nucleic acid analogs.F) A) and C)
G) C) and E)

Question 14

Ribavirin is an antiviral that interferes with

Accepted Answer

A)   protein synthesis.
B)   cell wall synthesis.
C)   cell membrane component synthesis.
D)   nucleic acid synthesis.
E)   viral attachment.F) A) and B)
G) C) and D)

Question 15

Second-generation drugs are semisynthetic drugs developed to combat __________ against an existing drug.

Accepted Answer

The answer of Second-generation drugs are semisynthetic drugs developed to...

Question 16

Which of the following statements is true of selective toxicity?

Accepted Answer

A)   Selective toxicity takes advantage of structural differences between host and pathogen.
B)   To be effective, an antimicrobial agent must be more toxic to the patient than the pathogen.
C)   Selective toxicity takes advantage of metabolic differences between host and pathogen.
D)   Antimicrobial agents must target structural differences between host and pathogen and be more toxic to the patient than the pathogen.
E)   Selective toxicity takes advantage of structural and/or metabolic differences between host and pathogen.F) B) and C)
G) A) and E)

Question 17

Which of the following is NOT a criterion by which all antimicrobial agents can be evaluated?

Accepted Answer

A)   their spectrum of action
B)   their efficacy
C)   their activity against cell walls
D)   their route of administration
E)   their safetyF) A) and B)
G) D) and E)

Question 18

Which of the following antifungals works by inhibiting ergosterol synthesis?

Accepted Answer

A)   fluconazole
B)   turbinafine
C)   amphotericin B
D)   nystatin
E)   both fluconazole and turbinafineF) A) and D)
G) A) and C)

Question 19

Antisense nucleic acids are designed to have no side effects against humans.

Accepted Answer

A) True 
 B)False

Question 20

Nucleotide or nucleoside __________are antimicrobial agents that mimic the chemical structure of DNA building blocks.

Accepted Answer

analogs

Exam 10: Controlling Microbial Growth in the Body: Antimicrobial Drugs

Methicillin is an example of the beta-lactam class of drugs that

Correct AnswerverifiedB

Examine the diffusion susceptibility plate results shown in Figure 10.9. Propose an explanation for the appearance of the zone around the AM/10 disk, and discuss the implications for therapeutic use of this antibiotic for the pathogen tested.

Correct AnswerverifiedThe ring of colonies within the outermos...View AnswerShow Answer

Competition between beneficial microbes and potential pathogens is called microbial __________.

Correct AnswerverifiedShow Answer

Paul Erhlich coined the term antibiotics for the "magic bullet" antimicrobials he pursued.

Correct AnswerverifiedShow Answer

Which of the following groups of drugs can become incorporated into the bones and teeth of a fetus?

Correct AnswerverifiedShow Answer

Which of the following pathways is specifically inhibited by sulfonamides?

Correct AnswerverifiedShow Answer

Brain and spinal cord infections are difficult to treat because most antimicrobial drugs cannot diffuse out of the blood into these organs.

Correct AnswerverifiedShow Answer

The tetracyclines interfere with

Correct AnswerverifiedShow Answer

If a subculture of an MIC test grows in an MBC test, the concentration of the drug was bactericidal.

Correct AnswerverifiedShow Answer

Which scientist coined the term antibiotic?

Correct AnswerverifiedE

Discuss the cellular factors that might make a drug's spectrum of action narrow rather than broad.

Correct AnswerverifiedWhen a drug is labeled "narrow-spectrum,...View AnswerShow Answer

Selective __________ means that a given antimicrobial agent is more toxic to a pathogen than to the host being treated.

Correct AnswerverifiedShow Answer

Antimicrobials that block protein synthesis by binding to the mRNA are

Correct AnswerverifiedShow Answer

Ribavirin is an antiviral that interferes with

Correct AnswerverifiedShow Answer

Second-generation drugs are semisynthetic drugs developed to combat __________ against an existing drug.

Correct AnswerverifiedShow Answer

Which of the following statements is true of selective toxicity?

Correct AnswerverifiedShow Answer

Which of the following is NOT a criterion by which all antimicrobial agents can be evaluated?

Correct AnswerverifiedShow Answer

Which of the following antifungals works by inhibiting ergosterol synthesis?

Correct AnswerverifiedShow Answer

Antisense nucleic acids are designed to have no side effects against humans.

Correct AnswerverifiedShow Answer

Nucleotide or nucleoside __________are antimicrobial agents that mimic the chemical structure of DNA building blocks.

Correct Answerverifiedanalogs

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The ring of colonies within the outermos...
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When a drug is labeled "narrow-spectrum,...
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