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Which of the following is the voltage sensor that initiates an increase in cytoplasmic calcium in response to an action potential?


A) dihydropyridine receptor
B) sodium channel
C) calcium pump
D) calcium- induced calcium release channel
E) ryanodine receptor

F) B) and E)
G) A) and E)

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(Single- unit / Multi- unit)smooth muscle contains pacemaker cells.

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Which muscle type contracts by the sliding- filament mechanism?


A) skeletal, smooth, and cardiac muscle
B) smooth muscle only (single- unit or multi- unit)
C) skeletal and smooth muscle only
D) skeletal muscle only
E) smooth and cardiac muscle only

F) C) and D)
G) B) and E)

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Intrafusal muscle fibers contribute directly to the tension produced during muscle contraction.

A) True
B) False

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What is the region of thin filaments that has no overlap with thick filaments called?


A) H zone
B) M line
C) A band
D) I band
E) Z line

F) A) and C)
G) A) and B)

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The decreased ability of a muscle to maintain a constant force of contraction during repetitive stimulation is called what?


A) fatigue
B) wasting
C) treppe
D) tetanus
E) O2 depletion

F) B) and E)
G) C) and D)

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The tension produced during skeletal muscle contraction can be increased by all of the following EXCEPT


A) initiating the contraction when the muscle is at its optimum length.
B) increasing the frequency of action potentials in the muscle fiber.
C) increasing the frequency of action potentials in the motor neuron innervating the muscle.
D) increasing the load on the muscle.
E) recruiting motor units.

F) C) and E)
G) A) and E)

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The interaction between actin and myosin in smooth muscle requires


A) the tropomyosin must be moved out of the way by troponin before myosin can bind to actin.
B) the interaction between calcium and troponin to expose the myosin binding site on the actin molecule.
C) that the calcium- calmodulin complex directly phosphorylates myosin light chain, allowing myosin to bind to actin.
D) that the calcium- calmodulin complex activates myosin light- chain kinase, which phosphorylates myosin thereby allowing it to bind with actin.
E) the activation of troponin, which stimulates myosin light- chain kinase to phosphorylate myosin light chain, allowing myosin to bind with actin.

F) D) and E)
G) A) and D)

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Oxidative phosphorylation is the primary energy source for cardiac muscle.

A) True
B) False

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The mechanism responsible for the size principle involves


A) larger sympathetic neurons that contain the greatest number of muscle cells and reach threshold easier than smaller neurons.
B) smaller motor neurons that innervate the least number of muscle cells and reach threshold easier than larger neurons.
C) larger motor neurons that innervate the greatest number of muscle cells and reach threshold easier than smaller neurons.
D) smaller motor units that contain the greatest number of muscle cells and reach threshold easier than larger neurons.
E) smaller sympathetic neurons that contain the least number of muscle cells and reach threshold easier than larger neurons.

F) A) and E)
G) None of the above

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Which type of skeletal muscle fiber fatigues rapidly?


A) fast
B) glycolytic
C) oxidative
D) slow
E) isotonic

F) B) and E)
G) A) and D)

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The speed with which smooth muscle cells contract is similar to fast glycolytic skeletal muscle cells.

A) True
B) False

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Some muscle cells have pacemaker activity. These include


A) skeletal muscle only.
B) skeletal, smooth, and cardiac muscle.
C) smooth and cardiac muscle only.
D) smooth muscle only (single- unit or multi- unit) .
E) skeletal and smooth muscle only.

F) A) and E)
G) None of the above

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Which of the following attaches muscle to bone?


A) motor end plate
B) actin and myosin
C) tendons
D) sarcoplasmic reticulum
E) sarcomeres

F) B) and D)
G) B) and C)

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In which muscle type do thick and thin filaments organize into sarcomeres?


A) skeletal and smooth muscle only
B) smooth muscle only (single- unit or multi- unit)
C) skeletal and cardiac muscle only
D) skeletal muscle only
E) smooth and cardiac muscle only

F) C) and D)
G) A) and D)

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What is the functional unit of skeletal muscle?


A) tendons
B) actin and myosin
C) sarcomeres
D) motor end plate
E) sarcoplasmic reticulum

F) A) and B)
G) A) and C)

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Which of the following generates the mechanical force of a muscle through crossbridge cycling?


A) sarcomeres
B) motor end plate
C) sarcoplasmic reticulum
D) actin and myosin
E) tendons

F) C) and D)
G) B) and E)

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A skeletal muscle cell produces force for only a small portion of its contractile cycle because only a small portion of the crossbridge cycle involves force generation.

A) True
B) False

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What anchors thin filaments together?


A) A band
B) I band
C) H zone
D) Z line
E) M line

F) A) and B)
G) C) and D)

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The two types of sensory endings found in muscle spindles are the annulospiral endings and


A) free endings.
B) Ruffini's corpuscle.
C) Pacinian corpuscle.
D) Merkel's disks.
E) flower- spray endings.

F) B) and C)
G) A) and C)

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