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Which of the following events occurs last?


A) IP3 (inositol triphosphate) is produced.
B) Epinephrine combines with membrane-bound receptor on smooth muscle cell.
C) Calmodulin binds to the enzyme that phosphorylates myosin and cross-bridges form.
D) IP3 stimulates Ca2+ release from the endoplasmic reticulum.
E) Ca2+ binds with calmodulin.

F) A) and B)
G) B) and D)

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Given the following list of organic molecules, which includes hormones? 1) Nucleic acid derivatives 2) Polypeptides 3) Steroids 4) Proteins


A) 1, 3, 4
B) 1, 2, 3
C) 2, 3, 4
D) 1, 2, 3, 4
E) 1, 2, 4

F) A) and D)
G) A) and C)

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Which chemical type of hormone has a longer half-life?


A) Lipid-soluble
B) Protein
C) Water-soluble
D) Amino acid derivative

E) A) and D)
F) B) and D)

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Which of the following is not a shared characteristic of endocrine and exocrine glands?


A) Secretions are released through ducts onto an epithelial surface
B) Manufacture substances that are released from cells of the gland
C) Composed of epithelial tissue
D) None of the choices are correct.

E) None of the above
F) A) and D)

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An intercellular chemical signal that is produced by neurons but functions like a hormone would be called a ________.


A) neuropathogen
B) neurotransmitter
C) neurocrine
D) neuropeptide
E) neurosynthesizer

F) None of the above
G) B) and C)

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Considering the following events in the nuclear receptor model, identify which of these events occurs in the nucleus. (1) Hormone receptor complex binds to DNA. (2) Messenger RNA directs synthesis of specific proteins. (3) Hormone binds to receptors in the nucleus (sometimes in the cytoplasm) . (4) Messenger RNA synthesis is activated. (5) Synthesized proteins produce the response of the cell.


A) 1, 3, 5
B) 1, 3, 4
C) 1, 2, 3
D) 3, 4, 5
E) All events occur in the nucleus.

F) A) and E)
G) C) and D)

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Receptors for most water-soluble hormones are located


A) in the cytoplasm of their target cells.
B) on the plasma membrane of their target cells.
C) in the lysosomes of their target cells.
D) on the nuclear membrane of their target cells.
E) on the endoplasmic reticulum of their target cells.

F) B) and C)
G) A) and B)

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Which of the following hormones is most likely to bind to intracellular receptors?


A) Growth hormone (GH) , a complex protein
B) Insulin, a large peptide hormone
C) Aldosterone, a cholesterol-based hormone

D) A) and B)
E) A) and C)

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Hormones are intercellular chemical signals that


A) are secreted into the external environment where they act.
B) affect only non-hormone producing organs or tissues.
C) help coordinate growth, development and reproduction.
D) operate primarily by positive feedback.

E) A) and D)
F) None of the above

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Parathyroid hormone is released when blood calcium levels decrease. This is an example of control by ________ stimuli.


A) hormonal
B) neural
C) humoral
D) visceral

E) A) and B)
F) None of the above

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Arrange the following events in proper sequence: (1) The activating hormone interacts with a membrane-bound receptor. (2) Cyclic AMP causes the cell to carry out a function characteristic for that specific hormone. (3) Adenylyl cyclase catalyzes the transformation of ATP to cyclic AMP. (4) Adenylyl cyclase is activated.


A) 1, 2, 3, 4
B) 1, 4, 3, 2
C) 3, 4, 2, 1
D) 1, 3, 2, 4
E) 1, 3, 4, 2

F) B) and D)
G) B) and C)

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The length of time needed to eliminate half of a dose of a hormone is called its ________.

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In ________, a cell increases the number of hormone receptors and becomes more sensitive to the hormone.


A) amplification
B) positive feedback
C) down-regulation
D) up-regulation

E) C) and D)
F) A) and B)

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The half-life of a hormone allows one to determine


A) the rate of hormone secretion.
B) the identity of a hormone.
C) the rate at which hormones are eliminated from the body.
D) the rate of action of a hormone.
E) the rate of travel through the blood to a target.

F) None of the above
G) B) and C)

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Increasing levels of thyroid hormones decrease TSH levels. This is an example of ________ feedback.

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Match the description with the type of receptor model. -Intracellular mediator


A) Nuclear receptor model
B) Membrane-bound receptor model

C) A) and B)
D) undefined

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Match the description with the type of receptor model. -Membrane channels may be opened or closed


A) Nuclear receptor model
B) Membrane-bound receptor model

C) A) and B)
D) undefined

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Match the chemical signal with the appropriate description. -Endocrine


A) Chemicals produced by neurons that function as hormones
B) Chemicals that act locally on nearby cells
C) Chemical secreted by presynaptic terminal
D) Influences same cell type from which it is secreted
E) Chemical secreted into blood by specialized cells; travels some distance to target tissues

F) A) and C)
G) A) and B)

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Which pattern of hormone secretion, exemplified by thyroid hormones, remains relatively constant over long periods of time?


A) Acute hormone secretion
B) Episodic hormone secretion
C) Chronic hormone secretion
D) Long-term hormone secretion

E) None of the above
F) B) and D)

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Hormone A is a large protein composed of several polypeptides. Hormone B is a small fatty acid derivative. Which of the following statement correctly predicts the way these hormones interact with their target cells?


A) Hormone A would bind to a membrane-bound receptor, while hormone B would bind to an intracellular receptor.
B) Hormone A would bind to an intracellular receptor, while hormone B would bind to a membrane-bound receptor.
C) Hormone A and hormone B would bind to membrane-bound receptors.
D) Hormone A and hormone B would bind to intracellular receptors.

E) A) and C)
F) None of the above

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