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Which of the following is true of RNA processing?


A) exons are cut out before mRNA leaves the nucleus
B) nucleotides are added at both ends of the RNA
C) ribozymes may function in the addition of a 5' cap
D) RNA splicing adds a poly-A tail to the mRNA

E) A) and B)
F) A) and C)

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Which of the following is true of a codon?


A) It never codes for the same amino acid as another codon.
B) It can code for more than one amino acid.
C) It can be either in DNA or in RNA.
D) It is the basic unit of protein structure.

E) A) and D)
F) A) and C)

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Which of the following statements about RNA processing is correct?


A) Exons are removed before mRNA leaves the nucleus.
B) Ribozymes may function in RNA splicing.
C) RNA splicing can be catalyzed by tRNA.
D) A primary transcript is often much shorter than the final RNA molecule that leaves the nucleus.

E) A) and B)
F) A) and C)

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Which component is directly involved in translation?


A) RNA polymerase
B) ribosome
C) spliceosome
D) DNA

E) A) and D)
F) None of the above

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Which of the following statements correctly describes the function of a signal peptide?


A) It directs an mRNA molecule into the lumen of the ER.
B) It terminates translation of messenger RNA.
C) It helps target a protein to the ER.
D) It signals the initiation of transcription.

E) A) and C)
F) All of the above

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Transcription in eukaryotes requires which of the following molecules in addition to RNA polymerase?


A) anticodons
B) ribosomes and tRNA
C) transcription factors
D) aminoacyl-tRNA synthetase

E) B) and C)
F) A) and D)

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Accuracy in translation of mRNA into the primary structure of a polypeptide depends on specificity in the ________.


A) binding of ribosomes to the mRNA
B) binding of the anticodon to small subunit of the ribosome
C) attachment of amino acid's carboxyl group with the amine of the next amino acid.
D) attachment of amino acids to tRNAs

E) B) and C)
F) A) and B)

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According to the central dogma, which of the following intermediate molecules correctly completes the flow chart describing the flow of information in a cell blank? DNA → ________ → Proteins


A) enzymes
B) rRNA
C) mRNA
D) tRNA

E) B) and C)
F) None of the above

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Which of the following statements is the most current description of a gene?


A) a unit of heredity that causes formation of a phenotypic characteristic
B) a DNA subunit that codes for a single complete protein
C) a DNA sequence that is expressed to form a functional RNA or polypeptide product
D) a discrete unit of hereditary information that consists of a sequence of amino acids

E) All of the above
F) A) and D)

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Which of the following processes occurs in prokaryotes but not in eukaryotes?


A) removing introns from pre-RNA
B) simultaneous transcription and translation of the same mRNA
C) translation in the absence of a ribosome
D) translocation into the ER

E) B) and C)
F) C) and D)

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Translation termination occurs when a ribosome interacts with which of the following structures?


A) the end of the mRNA molecule.
B) a stop codon
C) the 5′ cap
D) the poly-A tail

E) C) and D)
F) A) and B)

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Which of the following statements best describes the termination of transcription in prokaryotes?


A) RNA polymerase transcribes through the polyadenylation signal, causing proteins to associate with the transcript and cut it free from the polymerase.
B) RNA polymerase transcribes through the terminator sequence, causing the polymerase to separate from the DNA and release the transcript.
C) Once transcription has initiated, RNA polymerase transcribes until it reaches the end of the chromosome and releases.
D) RNA polymerase transcribes through a stop codon, causing the polymerase to stop advancing through the gene and release the mRNA.

E) None of the above
F) C) and D)

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Use the figure to answer the question. Use the figure to answer the question.   Which codon on the mRNA strand codes for the amino acid carried by the aminoacyl-tRNA represented in the figure? A)  5′-UGG-3′ B)  3′-GUG-5′ C)  5′-GUA-3′ D)  5′-UUC-3′ Which codon on the mRNA strand codes for the amino acid carried by the aminoacyl-tRNA represented in the figure?


A) 5′-UGG-3′
B) 3′-GUG-5′
C) 5′-GUA-3′
D) 5′-UUC-3′

E) A) and D)
F) All of the above

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Use this model of a eukaryotic primary transcript to answer the following question. E = exon and I = intron 5′-UTR E1 I1 E2 I2 E3 I3 E4 UTR-3′ If the primary transcript is processed and transported to the cytosol, which of the following molecules best represents the mRNA that will be produced?


A) 5′-UTR I1 I2 I3 UTR-3′
B) 5′-E1 E2 E3 E4-3′
C) 5′-UTR E1 E2 E3 E4 UTR-3′
D) 5′-E1 I1 E2 I2 E3 I3 E4-3′

E) None of the above
F) B) and C)

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A section of DNA has the base sequence shown in #1. A mutation in this DNA strand results in the base sequence shown in #2. What type of mutation does this change represent? #1 5' - AGCGTTACCGT-3' #2 5'-AGGCGTTACCGT-3'


A) a missense mutation
B) a point mutation
C) a silent mutation
D) frameshift mutation

E) A) and C)
F) A) and D)

Correct Answer

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Which of the following characteristics of gene expression is shared by eukaryotic and prokaryotic cells?


A) Translation occurs before transcription.
B) Transcription of an mRNA is temporally separated from its translation.
C) Ribosomes attach to the plasma membrane when producing secreted proteins.
D) Signal sequences are needed for the production of membrane proteins.

E) None of the above
F) A) and B)

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Which of the following statements best describes the significance of the TATA box in the promoters of eukaryotes?


A) It is the recognition site for the binding of a specific transcription factor.
B) It sets the reading frame of the mRNA during translation.
C) It is the recognition site for ribosomal binding during translation.
D) It is the recognition site for ribosomal binding during transcription.

E) C) and D)
F) B) and D)

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Which of the following properties is associated with a protein that will be secreted from a eukaryotic cell?


A) It must be translated by a ribosome that remains free within the cytosol.
B) Its signal sequence must target it to the ER.
C) Its signal sequence must be cleaved off as the polypeptide enters the ER.
D) Its signal sequence must target it to the plasma membrane.

E) B) and C)
F) B) and D)

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Which of the following molecules directly participates in the process of translation?


A) mRNA, tRNA, DNA, and rRNA
B) mRNA, DNA, and rRNA
C) mRNA, tRNA, and rRNA
D) mRNA, tRNA, and DNA

E) A) and B)
F) All of the above

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The anticodon of a particular tRNA molecule is ________.


A) complementary to the corresponding mRNA codon
B) complementary to the corresponding triplet in rRNA
C) the part of tRNA that bonds to a specific amino acid
D) catalytic, making the tRNA a ribozyme

E) C) and D)
F) B) and D)

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