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Match the following descriptions with the appropriate letter. Match the following descriptions with the appropriate letter.    -carboxyl group -carboxyl group

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The region on the DNA where the RNA polymerase initially binds is called the


A) termination sequence.
B) promoter.
C) stop codon.
D) start codon.
E) message.

F) B) and E)
G) A) and D)

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When genes are changed by mutations,this will never change the function of the proteins they encode.

A) True
B) False

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In cystic fibrosis,the most common mutation produces a non-functional protein that controls the flow of chloride ions into and out of the cell.

A) True
B) False

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PROBLEM Consider a stretch of DNA (a hypothetical gene) that has the sequence TACGATAGTACCAGGATT on the strand that will be transcribed. -Now,our hypothetical gene has undergone a mutation.The mutant sequence is TACGATACTACCAGGATT.Transcribe the mutant sequence into mRNA,and determine the amino acid sequence of the resulting polypeptide chain.Determine if the nucleotide modification produced a different amino acid sequence n the protein.What do you think the consequence of this mutation would be in terms of protein function?

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The mRNA would read AUGCUAUGAUUGGUCCUAA....

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An anticodon is


A) located on miRNA.
B) a group of nucleotides in mRNA that encodes the information for a specific amino acid in a protein.
C) a group of nucleotides in a tRNA molecule.
D) a chemical link formed between amino acids.
E) the enzyme that carries out transcription.

F) C) and D)
G) A) and E)

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A codon is


A) located on miRNA.
B) a group of nucleotides in mRNA that encodes the information for a specific amino acid in a protein.
C) a group of nucleotides in a tRNA molecule .
D) a chemical link formed between amino acids.
E) the enzyme that carries out transcription.

F) All of the above
G) A) and B)

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The signal on the mRNA that causes translation to stop is the


A) start codon.
B) termination tRNA.
C) stop codon.
D) start methionine.
E) termination sequence.

F) A) and C)
G) C) and D)

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MATCHING Match the term to the description. -mRNA


A) Binds to an amino acid
B) Consists of two subunits
C) Carries codons
D) Ends translation
E) Translation begins here
F) Forms between two amino acids

G) A) and F)
H) A) and B)

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RNA polymerase is the enzyme that


A) makes protein from a DNA template.
B) makes pre-mRNA from a DNA template.
C) transports RNA from the nucleus to the cytoplasm.
D) makes DNA from a RNA template.
E) replicates DNA.

F) B) and D)
G) A) and C)

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Match the following descriptions with the appropriate letter. Match the following descriptions with the appropriate letter.    -these are different for different amino acids -these are different for different amino acids

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MATCHING Match the term to the description. -Ribosome


A) Binds to an amino acid
B) Consists of two subunits
C) Carries codons
D) Ends translation
E) Translation begins here
F) Forms between two amino acids

G) E) and F)
H) B) and F)

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RNA polymerase makes mRNA from a DNA template.

A) True
B) False

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What distinguishes amino acids from one another?


A) different amino groups
B) different carboxyl groups
C) different R groups
D) All of these distinguish amino acids from one another.
E) None of these distinguish amino acids from one another.

F) B) and E)
G) B) and C)

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Changing how tightly the DNA is wound does not affect gene expression.

A) True
B) False

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What treatments are available for patients with sickle-cell anemia? What is the first drug treatment that has been approved? What are some of the negatives of this drug? Why do you think that the use of this drug needs to be monitored by a doctor? If you suffered from sickle-cell anemia,would you want to take this drug? Explain your answers.

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Treatments for patients with sickle-cell...

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All of the following are functions of proteins EXCEPT


A) provide structure.
B) receptors.
C) carrier molecules.
D) chemical messengers.
E) storage of genetic information.

F) A) and B)
G) C) and D)

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Gene regulation can be achieved by all of the following EXCEPT


A) the use of RNA interference.
B) controlling access to the promoter regions of genes.
C) chemically modifying histones.
D) chemically modifying DNA
E) controlling the rate of DNA replication.

F) B) and C)
G) A) and D)

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Which of the following answers best describes the flow of information when a gene directs the synthesis of proteins?


A) DNA→mRNA→tRNA
B) RNA→DNA→RNA→protein
C) DNA→mRNA→protein
D) Amino acid→mRNA→DNA
E) Lipids→mRNA→tRNA

F) All of the above
G) B) and C)

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How might a change in DNA nucleotide sequence of a gene cause a genetic disorder?


A) A change in one base pair in a gene can change a crucial amino acid in a protein.
B) A mutation can change the three-dimensional shape of a protein and cause defective protein folding.
C) A mutational change can cause a protein's subunits not to couple with each other properly.
D) The change can lead to production of a shortened, non-functional protein.
E) All of these are possible ways that changes in DNA could lead to genetic disorders.

F) C) and E)
G) B) and C)

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