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Symptoms of narcolepsy involving REM sleep (such as cataplexy) are effectively treated by drugs that


A) block serotonin receptors.
B) impair the release of hypocretins in the brain.
C) act as catecholamine antagonists.
D) are commonly used to treat depression.
E) promote GABA activity.

F) B) and E)
G) A) and E)

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Which of the following is true of sleep?


A) Strong movements accompany each sleep stage.
B) Sleep is preceded by a feeling of dizziness.
C) Humans spend about a third of their lives asleep.
D) Sleep is a state of unconsciousness.
E) The function of sleep is to suppress memory consolidation.

F) C) and D)
G) All of the above

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A common treatment for sleep apnea is


A) surgical modification of the airways.
B) sleeping medication.
C) sleep deprivation.
D) antidepressant medication.
E) a drug that activates brain norepinephrine synapses.

F) A) and D)
G) B) and D)

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The ________ brain wave pattern has a characteristic frequency of ________.


A) sleep spindle; 1-3 Hz
B) theta; 12-14 Hz
C) alpha; 13-30 Hz
D) sleep spindle; less than 3.5 Hz
E) theta; 3.5-7.5 Hz

F) A) and E)
G) All of the above

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Signs of cortical arousal in the EEG are induced by


A) adenosine.
B) GABA agonists.
C) serotonergic drugs.
D) acetylcholine agonists.
E) dopamine agonists.

F) C) and D)
G) A) and C)

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A potential treatment for jet lag is to administer ________ at ________.


A) amphetamine; noon
B) melatonin; bedtime
C) alcohol; boarding time
D) amphetamine; bedtime
E) melatonin; noon

F) All of the above
G) C) and E)

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A single cycle of non-REM/REM sleep lasts about


A) 10 minutes.
B) 30-40 minutes.
C) 90 minutes.
D) 360 minutes.
E) 8 hours.

F) C) and E)
G) B) and D)

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Which of the following is a reason why stage 4 is considered to be the deepest sleep stage?


A) A person in this stage is easily roused by meaningful stimuli.
B) A person who awakes from stage 1 is groggy and confused.
C) A person who awakes from this stage is alert and attentive.
D) Only very loud stimuli will awaken a person from stage 4 sleep.
E) Napping in stage 4 reduces the amount of sleep required per night.

F) B) and D)
G) C) and D)

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Sleep stages 1-4 are termed ________,whereas stages 3-4 are referred to as ________.


A) REM sleep; non-REM sleep
B) non-REM sleep; slow-wave sleep
C) slow-wave sleep; non-REM sleep
D) paradoxical sleep; REM sleep
E) arrhythmic sleep; paradoxical sleep

F) All of the above
G) B) and C)

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Damage to the ventrolateral preoptic area would be expected to


A) produce persistent REM sleep.
B) alter male reproductive behavior.
C) produce insomnia.
D) impair the control of temperature regulation.
E) reproduce the symptoms of narcolepsy.

F) B) and E)
G) B) and C)

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The primary symptom of REM-sleep behavior disorder is(are)


A) attacks of cataplexy.
B) a depressed mood upon awakening.
C) motor movements during slow-wave sleep.
D) the ability of a person to move during REM sleep.
E) loss of dreams during REM sleep.

F) C) and D)
G) None of the above

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The primary function of slow-wave sleep is to


A) clear brain waste products produced by REM sleep.
B) promote dreaming.
C) facilitate learning.
D) promote brain development.
E) permit the brain to rest.

F) A) and E)
G) All of the above

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The metabolism of glycogen increases the brain levels of ________,which in turn promotes ________.


A) GABA; slow-wave sleep
B) GABA; REM sleep
C) adenosine; slow-wave sleep
D) a benzodiazepine ligand; slow-wave sleep
E) adenosine; wakefulness

F) A) and B)
G) A) and D)

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Which of the following findings support the memory consolidation theory of REM sleep?


A) Deprivation of REM sleep results in poor learning in rats.
B) Active phases of brain development are associated with low levels of REM sleep.
C) Slow-wave sleep deprivation results in poor learning in rats.
D) Training in a complex maze reduces time spent in REM sleep.
E) REM sleep time is increased in retarded children relative to normal children.

F) A) and C)
G) A) and B)

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The major disorder suffered by Michael,the subject of the chapter prologue,was


A) a nighttime eating disorder.
B) an anxiety disorder.
C) narcolepsy.
D) a slow-wave sleep behavior disorder.
E) insomnia.

F) A) and B)
G) A) and E)

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Narcolepsy in dogs is


A) produced by a mutation of the hypocretin gene.
B) due to a flaw in the lateral hypothalamus.
C) a mutation of the leptin gene.
D) an environmental disorder.
E) associated with overeating to obesity.

F) A) and E)
G) A) and D)

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A person whose brain waves contain high-amplitude delta waves is most likely


A) in either stage 3 or 4 of slow-wave sleep.
B) in stage 1 of slow-wave sleep.
C) dreaming.
D) in stage 2 of slow-wave sleep.
E) awake.

F) A) and C)
G) All of the above

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The vlPOA is key region for the initiation of sleep.

A) True
B) False

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Explain why it is said that the brain is active during sleep.

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Circuits in the brain control the sequen...

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Which of the following is true of the sleep cycle during a night of sleep?


A) Each non-REM/REM cycle lasts about 45 minutes.
B) Subjects first enter REM sleep and then transition to non-REM sleep.
C) As the night goes on, the relative length of REM sleep increases in each successive cycle.
D) Stages 3 and 4 of slow-wave sleep mostly occur in the early morning hours.
E) Sleep cycles are random across the night.

F) B) and C)
G) B) and E)

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